“This is a major finding, because it provides a basis for future studies that will examine the effects of interventions that target the gut microbiota in the management of lupus,” said lead author Dr. Wael Jarjour, a rheumatologist and director of the Division of Rheumatology and Immunology at Ohio State.
Lupus is an autoimmune disease in which the body’s immune system attacks the body’s own cells and organs. Lupus affects predominantly young women and can be associated with significant internal organ damage.
“One of the environmental factors that plays a role is the various bacteria found in the gut, otherwise referred to as the gut microbiota. We examined the effects of a specific bacterium called segmented filamentous bacteria (SFB) in a lupus mouse model and demonstrated that the introduction of this bacterium causes severe worsening of lupus nephritis, a type of kidney disease caused by systemic lupus,” Jarjour said.
Colonization of these mice with this bacterium greatly enhances inflammatory kidney lesions, he said. The intestinal wall normally provides a barrier similar to skin, but it becomes “leaky” once this bacterium is introduced, thus allowing some material in the intestine to leak into the circulation. SFB also alters other types of bacteria that form the microbiota in these mice, resulting in a loss of the normal balance of different bacterial species, Jarjour said.
“This bacterium has been shown to be important in rheumatoid arthritis models, and we wanted to examine its effects in lupus. Our research establishes a mouse model to test various approaches to restore gut microbiota balance,” said first-author Giancarlo R. Valiente, who is a graduate of the Medical Scientist Training Program at The Ohio State University.
Researchers next plan to study if the eradication of this bacterium promotes improvement of lupus nephritis. This would lay the groundwork for examining the effects of modifying gut microbiota in lupus patients, Jarjour said. Kidney disease caused by lupus may get worse over time and lead to kidney failure. If this happens, dialysis or a kidney transplant would be needed.
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