World Health Organization. Coronavirus Disease (COVID-19)—World Health Organization. https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
World Health Organization. Critical Preparedness, Readiness and Response Actions for COVID-19: Interim Guidance, 22 March 2020. https://apps.who.int/iris/handle/10665/331511 (2020).
Wu, Z. & McGoogan, J. M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 323, 1239–1242 (2020).
Scherlinger, M. et al. Refining “long-COVID” by a prospective multimodal evaluation of patients with long-term symptoms attributed to SARS-CoV-2 infection. Infect. Dis. Ther. 10, 1747–1763 (2021).
Nalbandian, A. et al. Post-acute COVID-19 syndrome. Nat. Med. 27, 601–615 (2021).
Datta, S. D., Talwar, A. & Lee, J. T. A proposed framework and timeline of the spectrum of disease due to SARS-CoV-2 infection: Illness beyond acute infection and public health implications. JAMA 324, 2251–2252 (2020).
COVID-19 Rapid Guideline: Managing the Long-Term Effects of COVID-19. (National Institute for Health and Care Excellence (UK), 2020).
CDC. Healthcare Workers. Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-conditions.html (2020).
Venkatesan, P. NICE guideline on long COVID. Lancet Respir. Med. 9, 129 (2021).
The Lancet, null. Facing up to long COVID. Lancet Lond. Engl. 396, 1861 (2020).
Logue, J. K. et al. Sequelae in adults at 6 months after COVID-19 infection. JAMA Netw. Open 4, e210830 (2021).
Huang, C. et al. 6-month consequences of COVID-19 in patients discharged from hospital: A cohort study. Lancet Lond. Engl. 397, 220–232 (2021).
Davis, H. E. et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine 38, 101019 (2021).
Havervall, S. et al. Symptoms and functional impairment assessed 8 months after mild COVID-19 among health care workers. JAMA 325, 2015–2016 (2021).
Carfì, A., Bernabei, R., Landi, F., Gemelli Against COVID-19 Post-Acute Care Study Group. Persistent symptoms in patients after acute COVID-19. JAMA 324, 603–605 (2020).
Munblit, D. et al. Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19. Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol. https://doi.org/10.1111/cea.13997 (2021).
Akbarialiabad, H. et al. Long COVID, a comprehensive systematic scoping review. Infection https://doi.org/10.1007/s15010-021-01666-x (2021).
Günster, C. et al. 6-month mortality and readmissions of hospitalized COVID-19 patients: A nationwide cohort study of 8,679 patients in Germany. PLoS ONE 16, e0255427 (2021).
Boscolo-Rizzo, P. et al. Sequelae in adults at 12 months after mild-to-moderate coronavirus disease 2019 (COVID-19). Int. Forum Allergy Rhinol. https://doi.org/10.1002/alr.22832 (2021).
Wu, X. et al. 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study. Lancet Respir. Med. 9, 747–754 (2021).
Yan, X. et al. Follow-up study of pulmonary function among COVID-19 survivors 1 year after recovery. J. Infect. 83, 381–412 (2021).
Seeßle, J. et al. Persistent symptoms in adult patients one year after COVID-19: a prospective cohort study. Clin. Infect. Dis. https://doi.org/10.1093/cid/ciab611 (2021).
Budhiraja, S. et al. Long term health consequences of COVID-19 in hospitalized patients from North India: A follow up study of up to 12 months. Medrxiv. https://doi.org/10.1101/2021.06.21.21258543 (2021).
Sigfrid, L. et al. Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO clinical characterisation protocol. Lancet Reg. Health Eur. https://doi.org/10.1016/j.lanepe.2021.100186 (2021).
Huang, L. et al. 1-year outcomes in hospital survivors with COVID-19: A longitudinal cohort study. Lancet Lond. Engl. 398, 747–758 (2021).
World Health Organization. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance. Pediatr. Med. Rodz. 16, 9–26 (2020).
Italian Health Ministry. General Directorate of Health Prevention. Circular letter no. 11715 of April 1st 2021. Pandemia di COVID-19—Aggiornamento delle indicazioni sui test diagnostici e sui criteri da adottare nella determinazione delle priorità. Aggiornamento delle indicazioni relative alla diagnosi di laboratorio.
Duca, A., Piva, S., Focà, E., Latronico, N. & Rizzi, M. Calculated decisions: Brescia-COVID respiratory severity scale (BCRSS)/algorithm. Emerg. Med. Pract. 22, 1–2 (2020).
Italian Health Ministry. General Directorate of Health Prevention. Circular letter no. 8248 of March 3rd 2021. Vaccinazione dei soggetti che hanno avuto un’infezione da SARS-CoV-2.
Genecand, L. et al. Diagnostic and therapeutic management of medium and long-term sequelae of SARS-CoV-2 infection. Rev. Med. Suisse 17, 842–849 (2021).
Bestall, J. C. et al. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax 54, 581–586 (1999).
Enright, P. L. & Sherrill, D. L. Reference equations for the six-minute walk in healthy adults. Am. J. Respir. Crit. Care Med. 158, 1384–1387 (1998).
Wu, J. et al. Chest CT findings in patients with coronavirus disease 2019 and its relationship with clinical features. Invest. Radiol. 55, 257–261 (2020).
Kwee, T. C. & Kwee, R. M. Chest CT in COVID-19: What the radiologist needs to know. Radiogr. Rev. Publ. Radiol. Soc. N. Am. Inc 40, 1848–1865 (2020).
Infantino, M. et al. Diagnostic accuracy of an automated chemiluminescent immunoassay for anti-SARS-CoV-2 IgM and IgG antibodies: An Italian experience. J. Med. Virol. 92, 1671–1675 (2020).
Raghu, G. & Wilson, K. C. COVID-19 interstitial pneumonia: Monitoring the clinical course in survivors. Lancet Respir. Med. 8, 839–842 (2020).
Greenhalgh, T., Knight, M., A’Court, C., Buxton, M. & Husain, L. Management of post-acute covid-19 in primary care. BMJ 370, m3026 (2020).
Testa, S. et al. Implementation of tele visit healthcare services triggered by the COVID-19 emergency: The Trentino Province experience. Z. Gesundheitswissenschaften J. Public Health https://doi.org/10.1007/s10389-021-01609-8 (2021).
Ciarleglio, F. A. et al. The negative effects of COVID-19 and national lockdown on emergency surgery morbidity due to delayed access. World J. Emerg. Surg. WJES 16, 37 (2021).
Rigoni, M., Torri, E., Nollo, G., Delle Donne, L. & Cozzio, S. NEWS2 is a valuable tool for appropriate clinical management of COVID-19 patients. Eur. J. Intern. Med. 85, 118–120 (2021).
Lopez-Leon, S. et al. More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci. Rep. 11, 16144 (2021).
Aiyegbusi, O. L. et al. Symptoms, complications and management of long COVID: a review. J. R. Soc. Med. https://doi.org/10.1177/01410768211032850 (2021).
Jesuthasan, A., Massey, F., Manji, H., Zandi, M. S. & Wiethoff, S. Emerging potential mechanisms and predispositions to the neurological manifestations of COVID-19. J. Neurol. Sci. 428, 117608 (2021).
Baratta, J. M., Tompary, A., Siano, S., Floris-Moore, M. & Weber, D. J. Postacute sequelae of COVID-19 infection and development of a physiatry-led recovery clinic. Am. J. Phys. Med. Rehabil. 100, 633–634 (2021).
Crook, H., Raza, S., Nowell, J., Young, M. & Edison, P. Long covid-mechanisms, risk factors, and management. BMJ 374, n1648 (2021).
Fernández-de-Las-Peñas, C. et al. Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis. Eur. J. Intern. Med. S0953–6205(21), 00208–00209. https://doi.org/10.1016/j.ejim.2021.06.009 (2021).
Blanco, J.-R. et al. Pulmonary long-term consequences of COVID-19 infections after hospital discharge. Clin. Microbiol. Infect. Off. Publ. Eur. Soc. Clin. Microbiol. Infect. Dis. 27, 892–896 (2021).
Sideris, G. A. et al. Imaging in the COVID-19 era: Lessons learned during a pandemic. World J. Radiol. 13, 192–222 (2021).
Zhang, S. et al. Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors. Sci. Rep. 11, 13854 (2021).
Laing, E. D. et al. SARS-CoV-2 antibodies remain detectable 12 months after infection and antibody magnitude is associated with age and COVID-19 severity. medrxiv https://doi.org/10.1101/2021.04.27.21256207 (2021).
Xiao, K. et al. Antibodies can last for more than 1 year after SARS-CoV-2 infection: A follow-up study from survivors of COVID-19. Front. Med. 8, 684864 (2021).
Haveri, A. et al. Persistence of neutralizing antibodies a year after SARS-CoV-2 infection. medrxiv. https://doi.org/10.1101/2021.07.13.21260426 (2021).
Vitale, J. et al. Assessment of SARS-CoV-2 reinfection 1 year after primary infection in a population in Lombardy, Italy. JAMA Intern. Med. https://doi.org/10.1001/jamainternmed.2021.2959 (2021).
COVID-19 Vaccine Tracker | European Centre for Disease Prevention and Control. https://vaccinetracker.ecdc.europa.eu/public/extensions/COVID-19/vaccine-tracker.html#uptake-tab.
Pilati, F., Tronconi, R., Nollo, G., Heragu, S. S. & Zerzer, F. Digital twin of COVID-19 mass vaccination centers. Sustainability 13, 7396 (2021).
Nollo, G., Pilati, F, F., Tronconi, R. & Rigoni, M. Industry 4.0 at the service of public health against the COVID-19 pandemic. Disaster Med. Public Health Prep. In press,.
Garg, M. et al. The conundrum of ‘long-COVID-19’: A narrative review. Int. J. Gen. Med. 14, 2491–2506 (2021).
Menges, D. et al. Burden of post-COVID-19 syndrome and implications for healthcare service planning: A population-based cohort study. PLoS ONE 16, e0254523 (2021).
Rajan, S. et al. In the Wake of the Pandemic: Preparing for Long COVID. (European Observatory on Health Systems and Policies, 2021).
Herrera, J. E. et al. Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of fatigue in postacute sequelae of SARS-CoV-2 infection (PASC) patients. PM R https://doi.org/10.1002/pmrj.12684 (2021).
Schünemann, H. J. et al. Using GRADE in situations of emergencies and urgencies: certainty in evidence and recommendations matters during the COVID-19 pandemic, now more than ever and no matter what. J. Clin. Epidemiol. 127, 202–207 (2020).
Miglietta, A. et al. Health technology assessment applied to emergency preparedness: a new perspective. Int. J. Technol. Assess. Health Care 37, e77 (2021).
Grossi, A. et al. Hospital contextual factors affecting the implementation of health technologies: A systematic review. BMC Health Serv. Res. 21, 407 (2021).
Torri, E. & Nollo, G. Public health decision-making in the real world: Four points to reshape it after COVID-19. Disaster Med. Public Health Prep. https://doi.org/10.1017/dmp.2020.108 (2020).
