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Cold Supply Chain Limits Hurt Equitable COVID-19 Vaccination | Best Countries

By Timothy Ford and Charles M. Schweik

There are few places in the U.S. that are unreachable by road, but other factors – many rural hospitals can’t afford ultralow-temperature freezers or might not have reliable electricity, for example – present challenges. However, with government will and resources, these could be overcome.

That is not true for much of the rest of the world.

One of us, Tim Ford, is a global health researcher who has done a lot of international work on water and health where the cold supply chain cannot go, most recently in rural Haiti. The other, Charles Schweik, studies how the spread of innovations – both digital and physical – can solve pressing societal problems and social inequities.

The Pfizer and Moderna vaccines are a great start that should be celebrated, but they rely on a complicated supply chain of freezers and temperature-controlled shipping methods called the “cold chain.” That reliance on the cold chain raises equity and social justice concerns, since many parts of the world cannot support one. Researchers are working hard on vaccines that can avoid the logistical and economic nightmare of cold chain delivery.

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TOPSHOT - A resident (L) of the Domenico Sartor nursing home in Castelfranco Veneto, near Venice, hugs her visiting daughter on November 11, 2020 through a plastic screen in a so-called "Hug Room" amid the new coronavirus pandemic. - The Hug Room allows guests and their families to embrace each other, while remaining separate and protected from the contagious disease, still guaranteeing physical contact for mental and emotional wellbeing. (Photo by Piero CRUCIATTI / AFP) (Photo by PIERO CRUCIATTI/AFP via Getty Images)

Where the cold chain doesn’t go

In poorer areas, more remote parts of the world and in places where the mean daytime temperature is high and electricity is unavailable or spotty, there are no mechanisms to keep vaccines at low temperatures. There may in fact be no roads – let alone airports – in many of these places either. And even if roads exist, they may be impassable at certain times of the year or inaccessible for political reasons or because of civil unrest.

This is bad for public health and fails to be equitable and just.

Temperature-stable vaccines

Both companies are also working with the COVAX Facility, which describes itself as “a global risk-sharing mechanism for pooled procurement and equitable distribution of eventual COVID-19 vaccines.” The goal is to make vaccines available to all countries participating in the COVAX program, regardless of income levels. As of mid–December, 92 low- and middle-income countries have signed up.

Refrigeration is better than freezing, but for remote locations, room temperature is best, and researchers are working on thermostable COVID-19 vaccines that won’t need refrigeration. Techniques that remove the need for a vaccine cold chain have been used for many decades with success. Freeze-dried vaccines are one such example. The first thermostable vaccine was developed for smallpox in 1955 and is credited in part with the ultimate elimination of the disease.

Hope for COVID-19 vaccines?

So far, this is mostly basic research, but progress in this area would greatly help meet global health needs.

Given the limitations of the cold chain, there are public health, moral and ethical obligations that require investment in vaccines that can be delivered using non-cold-chain approaches. For people in many places, that is the only way they will ever get a vaccine.The Conversation

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