Kapadia, B. H. et al. Periprosthetic joint infection. Lancet 387, 386–394 (2016).
Nishitani, K. et al. Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant-associated Staphylococcus aureus osteomyelitis in mice to identify critical pathogen and host factors. J. Orthop. Res. 33, 1311–1319 (2015).
de Mesy Bentley, K. L. et al. Evidence of Staphylococcus aureus deformation, proliferation, and migration in canaliculi of live cortical bone in murine models of osteomyelitis. J. Bone Miner. Res. 32, 985–990 (2017).
The Group of Investigators for Streptococcal Prosthetic Joint Infection et al. The Not-So-Good Prognosis of Streptococcal Periprosthetic Joint Infection Managed by Implant Retention: The Results of a Large Multicenter Study. Clin. Infect. Dis. 64, 1742–1752 (2017).
Bloch, B. V., Shah, A., Snape, S. E., Boswell, T. C. J. & James, P. J. Primary hip and knee arthroplasty in a temporary operating theatre is associated with a significant increase in deep periprosthetic infection. Bone Jt. J. 99B, 917–920 (2017).
Block, J. E. & Stubbs, H. A. Reducing the risk of deep wound infection in primary joint arthroplasty with antibiotic bone cement. Orthopedics 28, 1334–1345 (2005).
Springer, B. D. The diagnosis of periprosthetic joint infection. J. Arthroplas. 30, 908–911 (2015).
McConoughey, S. J. et al. Biofilms in periprosthetic orthopedic infections. Future Microbiol. 9, 987–1007 (2014).
Zhu, H., Jin, H., Zhang, C. & Yuan, T. Intestinal methicillin-resistant Staphylococcus aureus causes prosthetic infection via ‘Trojan Horse’ mechanism: Evidence from a rat model. Bone Jt. Res. 9, 152–161 (2020).
Krezalek, M. A. et al. Can methicillin-resistant Staphylococcus aureus silently travel from the gut to the wound and cause postoperative infection? Modeling the ‘trojan Horse Hypothesis’. Ann. Surg. 267, 749–758 (2018).
Alverdy, J. C., Hyman, N. & Gilbert, J. Re-examining causes of surgical site infections following elective surgery in the era of asepsis. The Lancet Infectious Diseases vol. 20 e38–e43 (Lancet Publishing Group, 2020).
Masters, E. A. et al. Evolving concepts in bone infection: redefining “biofilm”, “acute versus chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”. Bone Res. 7, 1–18 (2019).
Thwaites, G. E. & Gant, V. Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?. Nat. Rev. Microbiol. 9, 215–222 (2011).
Muraille, E., Leo, O. & Moser, M. Th1/Th2 paradigm extended: Macrophage polarization as an unappreciated pathogen-driven escape mechanism? Front. Immunol. 5, 603 (2014).
Nishitani, K. et al. IsdB antibody-mediated sepsis following S. aureus surgical site infection. JCI Insight 5(19), e141164 (2020).
Löwik, C. A. M. M. et al. Obese patients have higher rates of polymicrobial and Gram-negative early periprosthetic joint infections of the hip than non-obese patients. PLoS ONE 14, e0215035 (2019).
Turner, J. R. Intestinal mucosal barrier function in health and disease. Nat. Rev. Immunol. 9, 799–809 (2009).
Fasano, A. & Shea-Donohue, T. Mechanisms of disease: The role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 416–422 (2005).
Arrieta, M. C., Bistritz, L. & Meddings, J. B. Alterations in intestinal permeability. Gut 55, 1512–1520 (2006).
Fasano, A. et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 355, 1518–1519 (2000).
Wang, W., Uzzau, S., Goldblum, S. E. & Fasano, A. Human zonulin, a potential modulator of intestinal tight junctions. J. Cell Sci. 113, 4435–4440 (2000).
Fasano, A. All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases. F1000Research 9, 69 (2020).
Shohat, N. et al. Hip and knee section, what is the definition of a periprosthetic joint infection (PJI) of the knee and the hip? Can the same criteria be used for both joints?: Proceedings of international consensus on orthopedic infections. J. Arthroplasty 34, S325–S327 (2019).
Peterson, D. A. & Jimenez Cardona, R. A. Specificity of the adaptive immune response to the gut microbiota. In Advances in immunology vol. 107 71–107 (2010).
Honda, K. & Littman, D. R. The microbiome in infectious disease and inflammation. Annu. Rev. Immunol. https://doi.org/10.1146/annurev-immunol-020711-074937 (2012).
Ruff, W. E., Greiling, T. M. & Kriegel, M. A. Host–microbiota interactions in immune-mediated diseases. Nat. Rev. Microbiol. 2020(18), 521–538 (2020).
Schluter, J. et al. The gut microbiota is associated with immune cell dynamics in humans. Nature 2020(588), 303–307 (2020).
Joeri, T. et al. Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction. Gut 69, 191–193 (2020).
Craig, S. & Alessio, F. Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. Tissue Barriers 4, e1251384 (2016).
Malíčková, M. et al. Fecal zonulin is elevated in Crohn’s disease and in cigarette smokers. Pract. Lab. Med. 9, 39–44 (2017).
Aleksandrova, K., Romero-Mosquera, B. & Hernandez, V. Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention. Nutrients 9(9), 962 (2017).
Hernandez, C. J. et al. Disruption of the gut microbiome increases the risk of periprosthetic joint infection in mice. Clin. Orthop. Relat. Res. https://doi.org/10.1097/CORR.0000000000000851 (2019).
Hasin, Y., Seldin, M. & Lusis, A. Multi-omics approaches to disease. Genome Biol. 18, 1–15 (2017).
Davey, M. E. & O’toole, G. A. Microbial biofilms: From ecology to molecular genetics. Microbiol. Mol. Biol. Rev. 64, 847–867 (2000).
Guégan, J.-F. The nature of ecology of infectious disease. Lancet Infect. Dis. 19, 1296 (2019).
Medzhitov, R. Recognition of microorganisms and activation of the immune response. Nature 2007(449), 819–826 (2007).
Zheng, D., Liwinski, T. & Elinav, E. Interaction between microbiota and immunity in health and disease. Cell Res. 2020(30), 492–506 (2020).
Johnson, P. T. J., Roode, J. C. de & Fenton, A. Why infectious disease research needs community ecology. Science. 349(6252), 1259504 (2015).
Shive, C. L., Jiang, W., Anthony, D. D. & Lederman, M. M. Soluble CD14 is a nonspecific marker of monocyteactivation. AIDS 29, 1263 (2015).
Rl, K. & Pa, T. Modulatory effects of sCD14 and LBP on LPS-host cell interactions. J. Endotoxin Res. 11, 225–229 (2005).
Sánchez-Alcoholado, L. et al. Gut microbiota-mediated inflammation and gut permeability in patients with obesity and colorectal cancer. Int. J. Mol. Sci. 21, 1–20 (2020).
Fasano, A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol. Rev. 91, 151–175 (2011).
Fasano, A. et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet (London, England) 355, 1518–1519 (2000).
Tajik, N. et al. Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nat. Commun. 11, 1995 (2020).
Zak-Gołąb, A. et al. Gut microbiota, microinflammation, metabolic profile, and zonulin concentration in obese and normal weight subjects. Int. J. Endocrinol. 2013, 674106 (2013).
Ciccia, F. et al. Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. Ann. Rheum. Dis. 76, 1123–1132 (2017).
Fasano, A. Intestinal permeability and its regulation by Zonulin: Diagnostic and therapeutic implications. Clin. Gastroenterol. Hepatol. 10, 1096–1100 (2012).
Li, C. et al. Zonulin regulates intestinal permeability and facilitates enteric bacteria permeation in coronary artery disease. Sci. Rep. 6, 29142 (2016).
